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c9,t11-CLA对人结肠癌细胞(Caco-2)的抑制作用

Inhibitory Effect of c9,t11-CLA on Human Colon Adenocarcinoma Cell Line Caco-2

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【作者】 陈燕黄桂东钟先锋唐浩国

【Author】 Chen Yan1,Huang Guidong1,2,Zhong Xianfeng2,Tang Haoguo2(1.Sino-German Joint Research Institute,Key Laboratory of Food Science of Ministry of Education,Nanchang University,Nanchang,Jiangxi 330047,China;2.College of Food Science and Bioengineering,He’nan University of Science and Technology,Luoyang,He’nan 471003,China)

【机构】 南昌大学中德联合研究院食品科学教育部重点实验室河南科技大学食品科学与生物工程学院

【摘要】 采用体外细胞培养方法,通过MTT实验,研究了c9,t11-CLA(Conjugated Linoleic acid,CLA)在不同浓度,(0,25,50,100,200μmol/L)、不同作用时间(1,2,3,4 d)下,对人结肠癌细胞Caco-2增殖的影响。结果表明,c9,t11-CLA抑制了Caco-2细胞的增殖,且对Caco-2细胞增殖的抑制作用与浓度和作用时间密切相关。

【Abstract】 The test was done by means of MTT assay in cell culture to observe the effects of different concentrations(0,25,50,100,200 μmol/L) of c9,t11-CLA on the proliferation of Caco-2 cell line in varying action time(1,2,3,4 d).The results showed that the Caco-2 cell proliferation could be inhibited by c9,t11-CLA.The activity was also closely related to the treatment time and concentration.

【基金】 河南科技大学校青年基金(2006QN011)
  • 【文献出处】 农产品加工(学刊) ,Academic Periodical of Farm Products Processing , 编辑部邮箱 ,2009年06期
  • 【分类号】R735.35
  • 【被引频次】1
  • 【下载频次】130
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