【摘要】 目的了解个体从业健康体检人员亚临床甲状腺功能减退症(SCH)的患病率,并观察SCH血清促甲状腺激素(TSH)与血脂的相关性因素分析。方法选取个体从业健康体检人员血清2958份,采用化学免疫分析法测定TSH、游离三碘甲状腺原氨酸(FT3)、游离四碘甲状腺原氨酸(FT4)。血生化指标采用全自动生化检测仪测定。结果个体从业健康体检人员SCH总检出率7.03%,其中女性检出率(8.95%)高于男性检出率(4.79%,<0.01)。从年龄结构看:50～59岁组检出率最高(11.73%),其次是18～29岁组和60岁以上组。男性TSH与尿酸(UA)、血糖(GLU)呈正相关,与载酯蛋白A(ApoA)呈负相关。结论个体从业健康体检人员SCH总患病率较上海(6.1%)、南昌地区(6.1%)高,不同性别、年龄患者TSH血浓度对血脂的影响各不相同。更多还原

【Abstract】 Objective To investigate the prevalence of subclinical hypothyroidism(SCH) in independent merchant.Methods From January to december 2007, serum levels of TSH, FT3 and FT4 by chemilumino-immunoassay and lipid profile in 2958 subjects were determined in independent merchant.Results(1)The overall SCH prevalence was 7.03%.(2)The SCH prevalence was significantly higher in females(8.95%) than that in males(4.79%).(3)The relationship between the SCH prevalence in the sex and the age showed that the highest SCH prevalence was in the 50 years old group(11.73%), with followed by 18 years old group(7.42%) and the 60 years old group(7.37%).Serum TSH was closely in postive corelation with plasma UA and GLU levels in males(P<0.01).Serum TSH was closely in postive corelation with plasma TG, TC and ApoB levels in females(P<0.01).Serum TSH was closely in nagetive corelation with plas-ma HDL、ApoA1 levels in two group.Conclusion The SCH prevalence is higher in independent merchant than that in Shanghai, Nanchang area.The serum TSH levels in famels and mels have a different effect on lipid.更多还原