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甘蔗烷醇预防给药对家兔高脂血症模型的影响研究

Study on prophylactic Sugarcane Alkane Alcohol to rabbit Hyperlipidemia Model

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【作者】 石忠峰姚光辉赵金华

【Author】 SHI Zhong-feng1YAO Guang-hui2ZHAO Jin-hua2,3(1.Guangdong Pharmaceutical University,Center Laboratory,Guangdong,Guangzhou,510006;2.Shenzhen Neptunus Pharmaceutical Company Limited,Guangdong,Shenzhen,518057;3.Shenzhen Haichuang Medicine technology Company Limited,Guangdong,Shenzhen,518057)

【机构】 广东药学院中心实验室深圳海王药业有限公司深圳海创医药科技发展有限公司

【摘要】 目的:研究甘蔗烷醇在预防高脂血症方面的药用价值。方法:采用兔复制高脂血症模型,采用甘蔗烷醇提取物预防给药,观察对模型动物甘油三酯及胆固醇的影响。结果:预防给药实验12周后,甘蔗烷醇10、5、2.5mg/kg均可非常显著降低TC、TG、LDL-C,10mg组可显著提高HDL-C。结论:甘蔗烷醇预防给药对家兔高脂血症模型具有良好的调节血脂作用。

【Abstract】 Purpose:To study effect ofsugarcane alkane alcohol on hyperlipidemia Prevention.Methods:To duplicatehyperlipidemia model with rabbits,preventively administrated sugarcane alkane alcohol,observe influence of Sugarcane Alkane Alcohol to model animals’ blood fat and cholesterol level.Result: After prophylactic administration for 12 weeks,TC,TG and LDL-C level in blood serum of hyperlipidemia markedly decreased after administered Sugarcane Alkane Alcohol by dose of 10mg/kg,5mg/kg and 7.5mg/kg,HDL-C markedly increased with 10 mg/kg.Conclusion: Sugarcane Alkane Alcohol has satisfactory pharmacologic actions on hyperlipidemia animal model by regulating blood fat and cholesterol level with prophylactic administration.

【基金】 科技部科技型中小企业技术创新基金资助项目(NO.07C26214420778)
  • 【文献出处】 中国民族民间医药 ,Chinese Journal of Ethnomedicine and Ethnopharmacy , 编辑部邮箱 ,2009年12期
  • 【分类号】R96
  • 【下载频次】96
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