【摘要】 乙型肝炎病毒(Hepatitis B Virus,HBV)是一种嗜肝细胞、非细胞毒性的双链DNA病毒。多数免疫功能健全人感染HBV后,可依靠固有免疫应答和适应性免疫应答的协调作用清除病毒,但仍有少数感染者不能有效地清除HBV,导致病毒的持续感染。造成乙型肝炎病毒持续感染的原因是十分复杂的,涉及到病毒本身和宿主免疫系统的多个方面因素,因此乙型肝炎病毒持续感染的机制引起了人们的广泛兴趣。目前虽有诸多实验结果和理论,但尚无完全令人满意的解释,总结乙型肝炎病毒持续感染机制的研究进展可为预防和控制乙型肝炎及选择合理的治疗药物提供新的思路。更多还原

【Abstract】 Hepatitis B virus(HBV)is a kind of non-cytotoxic,double-stranded DNA virus.Although most people with normal immune function can eliminate HBV depending on the association of innate and adaptive immune response,there are still some people who can’t clear away it effectively.The reason for persistent infection of HBV is complicated,and so the mechanism has caused extensive attention of researchers.Although there have been a lot of experimental results and theories recently,completely satisfying explanation has not been made.Therefore,a summary on the advances in the mechanism of persistent infection of HBV is necessary for approach to therapy of hepatitis B.更多还原