【摘要】 目的探讨狼疮性肾炎（LN）患者尿单核-巨噬细胞趋化蛋白-1（MCP-1）和转化生长因子-β₁ （TGF-β₁）检测的临床意义。方法对57例经肾活检证实为LN患者的尿MCP-1和TGF-β₁水平进行检测,24名健康者为正常对照组。结果与正常对照组比较,57例LN患者尿MCP-1和TGF-β₁增高（P<0.05）,LN-Ⅳ型尿MCP-1和TGF-β₁明显高于LN-Ⅱ和LN-Ⅲ型（P<0.05）,LN-Ⅴ和LN-Ⅵ型尿MCP-1无改变（P>0.05）,而尿TGF-β₁增高（P<0.05）;在活动期和非活动期LN患者尿MCP-1和TGF-β₁水平高于正常对照组（P<0.01）,活动期尿MCP-1和TGF-β₁水平明显高于非活动期（P<0.05）;LN-Ⅳ型尿MCP-1和TGF-β₁水平与24 h尿蛋白定量、血肌酐呈明显正相关（r=0.621、0.711,P<0.05;r=0.568、0.631,P<0.05）。LN-Ⅱ、LN-Ⅲ、LN-Ⅴ、LN-Ⅵ型尿MCP-1和TGF-β₁与24 h尿蛋白定量和血肌酐无明显相关性（P>0.05）;尿MCP-1水平与肾脏活动指数成正相关（r=0.681,P<0.05）,尿TGF-β₁与慢性化指数密切相关（r=0.605,P<0.05）。结论尿MCP-1和TGF-β₁水平可作为反映LN病情变化,判断病理类型的重要指标。更多还原

【Abstract】 Objective To investigate clinical significance of urinary monocyte chemoattractant protein-1（MCP-1） and transforming growth factor-beta（TGF-β₁） in patients with lupus nephritis （LN）.Methods 57 patients with LN were selected in this study,and 24 healthy people as control.All the level of urinary MCP-1 and TGF-β₁ were detected by ELISA.Results In 57 patients with LN,the levels of urinary MCP-1 and TGF-β₁ were significantly increased in class LN-Ⅱ,LN-Ⅲand LN-Ⅳcompared with those of the control（P<0.05）,and they were more higher in LN-Ⅳthan those in LN-Ⅱand LN-Ⅲ（P<0.05）.There was no difference between the levels of urinary MCP-1 in LN-Ⅴand LN-Ⅵand those of the control,but the levels of urinary TGF-β₁ in LN-Ⅴand LN-Ⅵwere significantly increased compared with the controls（P<0.05）. The levels of urinary MCP-1 and TGF-β₁ were significantly increased in active phase compared with remission phase,but still higher in remission phase than those in control（P<0.05）.The levels of urinary MCP-1 and TGF-β₁ in class LN-Ⅳwere positively correlated with 24 h urinary protein quantitative determination（r=0.621,P<0.05;r=0.711,P<0.05）;and were positively correlated with serum creatinine（r=0.568,P<0.05:r=0.631,P<0.05）.No correlation was found in other classification.MCP-1 in urine was positively correlated with SLEDAI（r=0.681, P<0.05）;and TGF-β₁ in urine was positively correlated with chronic index（r=0.605,P<0.05）. Conclusion The levels of urinary MCP-1 and TGF-β₁ can be used as an important predictor to assess disease activity,to estimate pathological type change in LN.更多还原