【摘要】 目的探讨非酒精性单纯脂肪肝(sNAFLD)患者血浆血管紧张素Ⅱ1型受体相关蛋白内源性配体(apelin)水平的变化。方法采用酶联免疫法测定42例sNAFLD患者和25例正常健康人空腹血浆apelin水平,分析其水平与体重指数、腰围、腰臀比、血压、空腹血糖、空腹血清胰岛素、稳态模型胰岛素抵抗指数、血脂等的关系。结果sNAFLD组的血浆apelin水平高于正常对照组(P<0.05);血浆apelin水平与体重指数、空腹血糖、收缩压、低密度脂蛋白、腰围、腰臀比、总胆固醇、空腹血清胰岛素、稳态模型胰岛素抵抗指数呈正相关(r=0.294～0.802,P<0.05);多元线性回归分析表明,总胆固醇、胰岛素抵抗指数分别是影响血浆apelin水平的独立相关因素。结论血浆apelin水平与胰岛素抵抗和脂代谢紊乱有关,并可能与sNAFLD的发生、发展具有一定的相关性。更多还原

【Abstract】 Objective To investigate the changes of apelin levels of type 1 receptor associated protein of angiotensinⅡand its correlation factors in patients with simple nonalcoholic fatty liver disease(sNAFLD).Methods Fasting plasma apelin was detected by enzyme linked immunosorbent assay(ELISA) in 42 patients with sNAFLD and 25 healthy controls,and its relationship with body mass index,waistline,waist-to-hip ratio,blood pressure,fasting plasma glucose,fasting serum insulin,homeostasis model assessment-insulin resistance index(HOMA-IR) and blood lipid was analyzed.Results Fasting plasma apelin levels in sNAFLD group were significantly higher when compared with controls,and positively correlated with body mass index,fasting plasma glucose,systolic blood pressure,lower-density lipoprotein,waistline,waist-to-hip ratio, total cholesterol,fasting serum insulin and HOMA-IR(r=0.294～0.802,P<0.05).Multiple regression analysis showed that HOMA-IR and total cholesterol were independent correlation factors to plasma apelin levels.Conclusion The changes of apelin levels are associated with insulin resistance and dyslipidosis,and may contribute in part to the pathogenesis of sNAFLD.更多还原