【摘要】 目的探讨白细胞介素-18(IL-18)、干扰素-γ(IFN-γ)在化脓性脑膜炎(BM)及复发-缓解型多发性硬化(RRMS)发病中的可能的病理生理机制。方法选取RRMS急性期患者24例,BM患者8例及作为对照组的非炎性神经系统疾病(NIND)患者12例,应用ELISA法测定受试者血清及脑脊液中IL-18、IFN-γ水平。结果与NIND组相比,RRMS组血清IL-18水平显著升高,而血清IFN-γ水平无明显差异,但两者间呈显著正相关。脑脊液中IL-18、IFN-γ在RRMS组和NIND组检测到的阳性例数极低,相比之下无统计学差异。与NIND组相比,BM组血清中IL-18水平明显升高,但无统计学差异,而血清中IFN-γ及脑脊液中的IL-18、IFN-γ水平在BM组中均有显著性升高。结论IFN-γ及IL-18参与了多发性硬化及化脓性脑膜炎这两种不同的中枢神经系统炎性疾病的免疫病理生理学机制。更多还原

【Abstract】 Objective To investigate the possible pathophysiologic role of interleukin-18(IL-18) and interferon-r(IFN-γ) in relapsing-remitting form of multiple sclerosis(RRMS)and bacterial meningitis(BM).Methods The concentration of IL-18 and IFN-γ in CSF and serum of 24 RRMS patients in the active stages,8 BM patients and 12 non-inflammatory neurological diseases(NIND) patients was measured by ELISA.Results The IL-18 concentrations in serum were significantly increased in RRMS,while IFN-γ in serum had no significant differences compared with NIND,but there was a statistically significant positive correlation between them.IL-18 and IFN-γ in CSF were detectable only in few patients with RRMS and NIND.The levels of IL-18 in serum of BM were increased respectively compared to NIND,but had no significant differences.IFN-γ in serum and IL-18、IFN-γ in CSF were significantly increased in BM in comparison with NIND.Conclusion The results suggest IL-18 and IFN-γ were involved in the immunopathogenesis of bacterial meningitis and multiple sclerosis-the different inflammatory diseases of CNS.更多还原