【摘要】 目的探讨α-inhibin及其受体β-glycan在恶性卵巢上皮性肿瘤中的表达,评估两种多肽信号对卵巢癌生长的调控作用,探讨卵巢癌的发病机制。方法应用EliVision方法检测30例正常卵巢组织、30例卵巢囊腺瘤和80例卵巢囊腺癌中α-in-hibin及其受体β-glycan的表达。结果α-inhibin在正常卵巢、卵巢囊腺瘤和卵巢囊腺癌中的总阳性表达率分别为93.3%、60.0%、36.3%,差异均有显著性(P<0.01);β-glycan在正常卵巢、卵巢囊腺瘤、卵巢囊腺癌的阳性表达率呈逐渐下降的趋势分别为100%、80.0%、75.0%,卵巢囊腺瘤、囊腺癌与正常卵巢组比较,差异有显著性(P<0.05),但卵巢囊腺瘤与囊腺癌比较,差异无显著性(P>0.05)。结论α-inhibin蛋白在卵巢囊腺癌中表达明显下降,而β-glycan在卵巢肿瘤中的表达仍然很高,提示β-glycan对增强α-inhibin抑制卵巢囊腺癌的形成可能起着一定的作用。更多还原

【Abstract】 Purpose To investigate the protein expression of α-inhibin and receptor β-glycan in malignant ovarian epithelial tumors,to evaluate the role of these two polypeptids in regulating the growth of ovarian cancer,and to explore the tumouriogenesis of ovarian cancer as well.Methods The expression of α-inhibin and β-glycan were examined with immunohistochemical EliVision method in 30 cases of normal ovary tissue,30 ovarian cystadenomas and 80 ovarian cystadenocarcinomas.Results The total positive rates of α-inhibin immunostaining in 30 normal ovary tissue,30 ovarian cystadenomas and 80 ovarian cystadenocarcinomas were 93.3%,60.0% and 36.3%,respectively,and there were significant difference between three groups (P<0.01).The total positive rates of β-glycan immunostaining in 30 normal ovary tissue,30 ovarian cystadenomas and 80 ovarian cystadenocarcinomas were 100%,80.0% and 75.0%,respectively,and there were also significant difference between normal ovary and ovarian cystadenoma groups(P<0.05),but no statistical difference between the cystadenoma and cystadenocarcinoma (P>0.05).Conclusions The expression of α-inhibin is significantly decreased in ovarian cystadenocarcinoma,but the expression of β-glycan is still high,suggesting that β-glycan overexpression may play a role in the carcinogenesis of ovarian neoplasm.更多还原