【摘要】 目的:探讨以补脾肾化瘀毒法治疗多发性骨髓瘤(MM)患者溶骨病变的临床疗效。方法:将40例MM患者随机分成2组,对照组20例予M2方案化疗,中药组20例予中药毒结清口服液60mL/d,同时予M2方案化疗。以血钙和CRP水平下降,骨痛的缓解和生活质量改善为评价指标。结果:中药组和对照组治疗后骨痛症状评分均明显下降,与治疗前比较差异均有显著性意义(P<0.05);中药组生活质量总有效率为70%与对照组总有效率(45%)比较差异均有显著性意义(P<0.05);中药组治疗后血钙和CRP水平均明显下降(P<0.05),与对照组治疗后血钙和CRP水平比较差异也有显著性意义(P<0.05);对照组治疗后血钙水平较治疗前下降(P>0.05);对照组CRP水平明显下降,与治疗前比较差异有显著性意义(P<0.05)。结论:补脾肾化瘀毒法联合化疗能有效降低MM患者血钙和CRP水平,改善骨痛症状,提高生活质量。更多还原

【Abstract】 Objective:To observe the effects of Bupishen-huayudu method in combination with Chemotherapy on patients with osteolytic lesions in Multiple Myeloma( MM). Methods:40Patients were randomly divided to two groups,control group were treated with M2 chemotherapy. In addition to M2 chemotherapy,TCM group were also treated with Dujieqing Liquor. Results:Scores of bone ache in group TCM and in group control were lower than pretherapy( P < 0. 05). Total effective rate of life quality in group TCM was higher than those in group control( P < 0. 05). Blood calcium and CRP lever in group TCM were lower than those in group control( P < 0. 05). Conclusion:Method of bupishen -huayudu combined with Chemotherapy could degrade blood calcium and CRP lever,also could improve symptom of bone ache and quality of life.更多还原