【摘要】 目的:研究3′-大豆苷元磺酸钠(DSS)对离体心脏缺血再灌注损伤的保护作用及NO、ANG Ⅱ和ANP含量的变化。方法:应用大鼠离体心肌缺血再灌注损伤模型,在灌流液中加入高、中、低剂量的DSS。测定冠脉流量、左心室收缩压及心肌组织NO、ANG Ⅱ和ANP含量的变化。结果:各剂量的3′-大豆苷元磺酸钠均能有效地增加冠脉流量,增强左心室收缩压;三种剂量的DSS均能升高心肌组织NO含量(P<0.05);高剂量的DSS使心肌组织ANG Ⅱ(P<0.05)含量降低,低剂量的DSS使ANP含量升高(P<0.05)。结论:DSS可通过增加NO、ANP的合成,减少ANG Ⅱ的释放,扩张冠脉,增强心肌收缩力,从而对离体心脏缺血再灌注损伤起保护作用。更多还原

【Abstract】 Objective:To explore the therapeutic effects of 3′-daidzein sulfonate sodium(DSS)on isolated myocardial ischemia/reperfusion injury and its effects on the levels of NO,ANG Ⅱ and ANP.Methods:An isolated rat myocardial ischemia/reperfusion injury was made and treated with DSS.The coronary artery blood flow levels,left ventricular systolic pressure,and the levels of NO,ANG Ⅱ and ANP were measured.Results:The isolated myocardial ischemia/reperfusion injury treated with DSS showed elevations in coronary blood flow levels and left ventricular systolic pressure.Moreover:enhance in concentration of NO in three doses groups(P<0.05),a decrease in the ANG Ⅱ levels in the high-dose groups(P<0.05),and an elevation in the ANP levels in the low-dose groups(P<0.05)were observed.Conclusion:DSS has a therapeutic effect on isolated myocardial ischemia/reperfusion injury by modulating the levels of NO,ANG Ⅱ and ANP,it dilates the coronary artery and enhances the myocardial contractile force.更多还原