【摘要】 目的观察无症状性脑梗死（silent cerebral infarction,SCI）患者血清炎性因子和纤溶及抗纤溶活性的变化。方法选择SCI患者53例（SCI组）和健康体检者55例（对照组）,分别检测血清高敏C反应蛋白（hs-CRP）、血浆纤溶酶原活性（PLG:A）、纤溶酶活性（PLM:A）、组织型纤溶酶原激活物（t-PA）活性、D-二聚体（D-D）含量、₂α-纤溶酶抑制剂（α₂-PI）和纤溶酶原激活物抑制剂（PAI）活性。结果 SCI组hs-CRP水平明显高于对照组[（15.36±4.30）mg/L vs （10.26±2.61）mg/L,P<0.01],SCI组PLM:A、t-PA和D-D含量均明显低于对照组[（35.84±10.23）% vs （68.74±18.41）%,（0.11±0.01）U/ml vs （0.49±0.12）U/mL（0.36±0.14）mg/L vs （0.68±0.16）mg/L,P<0.01)],SCI组PLG:A与对照组比较差异无统计学意义（P>0.05）,SCI组α₂-PI活性和PAI活性明显高于对照组[（128.46±23.75）% vs （96.36±19.34）%,（0.86±0.22）AU/ml vs （0.48±0.10）AU/ml.P<0.01]。结论炎症过程和纤溶及抗纤溶系统的功能失调与SCl的形成有关。更多还原

【Abstract】 Objective To observe the changes of serum inflammatory cytokine,fibrinolytic and antifibrinolytic activities in patients with silent cerebral infarction（SCI）. Methods The serum level of high-sensitivity C-reactive protein（hs-CRP） was measured by immunodiffusion turbidimetry in 53 patients with SCI and 55 cases of control group. The plasminogen activity（PLG : A）,plasmin activity（PLM : A）, tissue-type plasminogen activator （t-PA） activity, D-dimer （D-D）, α₂-plasmin inhibitor（α₂-PI） activity and plasminogen activator inhibitor（PAI） activity were also measured in both groups. Results The level of hs-CRP was significantly higher in patients with SCI than in the control group[（15.36±4.30） mg/L vs （10.26±2.61） mg/L, P<0.01]. The levels of PLM : A,t-PA and D-D were markedly lower in SCI group than in the control group [（35.84± 10.23）% vs （68.74±18.41）%,（0.11±0.01） U/ml vs （0.49±0.12） U/ml, and（0.36±0.14） mg/L vs （0.68±0.16） mg/L, P<0.01, respectively],but PLG : A was not significantly different between the two groups （P>0.05）. The α₂-PI activity and PAI activity were significantly higher in SCI group than in the control group[（128.46±23.75）% vs （96.36±19.34）%,（0.86± 0.22） AU/ml vs （0.48±0.10） AU/ml, P<0.01, respectively]. Conclusion Inflammatory processes and dysfunction of fibrinolytic and antifibrinolytic systems are involved in the pathogenesis of SCI.更多还原