【摘要】 目的:探讨Survivin在食管癌患者外周血中的表达与化疗敏感性及预后的关系。方法:采用荧光定量RT-PCR法检测Survivin mRNA在103例食管癌患者和正常人外周血中的表达,分析食管癌患者外周血中Survivin mRNA表达水平高低与不同化疗方案敏感性的关系,以及对生存期的影响。结果:FP、TP方案的疗效与外周血Survivin mRNA表达水平呈负相关,而NP方案疗效与外周血Survivin mRNA表达水平无关。总生存期与外周血Survivin mRNA表达水平有关,外周血Survivin mRNA表达水平低,总生存期长。结论:检测外周血Survivin mRNA对食管癌生存期预测以及化疗方案选择具有一定的指导作用。更多还原

【Abstract】 Objective:To investigate the relationship of expression of survivin in the peripheral blood of esophageal cancer to chemosensitivity and prognostic significance.Methods:Real-time fluorescence quantitative PCR was used to detect the expression of survivin mRNA in the peripheral blood samples abtained from 103 patients with esophageal cancer.Meanwhile,the correlation of expression of survivin in the peripheral blood of esophageal cancer to chemosensitivity and prognostic significance was identified.Results:The expression of survivin mRNA in the blood was inversely correlated with the effect of FP and TP regimens.However,the expression of survivin mRNA in the blood was not correlated with the effect of the NP regimen.Moreover,overall survival(OS) for patients with high survivin mRNA expression was less than that for patients with low survivin mRNA group expression.Conclusion:The expression of survivin mRNA in the peripheral blood of patients with esophageal cancer can prognosticate OS and choice the regimen of chemotherapy.更多还原