【摘要】 目的:探讨卵巢囊性成熟型畸胎瘤伴类癌的临床病理特征。方法:观察2例女性卵巢囊性成熟型畸胎瘤伴梁索型类癌患者的临床病理情况,并结合相关文献复习进行讨论。结果:2例卵巢梁索型类癌均伴有囊性成熟型畸胎瘤成份,患者行患侧输卵管-卵巢切除术,光镜下以疏松-丰富的纤维性间质所分隔的长条形、波浪状、平行排列的细胞带为特征。细胞带由柱状细胞组成,通常为1～3个细胞的厚度,长形的细胞核垂直于细胞带的长轴排列。中等丰富的嗜酸性胞浆,细胞核含有细腻、分散的染色质,核分裂像少见。免疫组化染色标记CgA、Syn、CD99、Ckpan均为阳性。结论:病理形态学观察和免疫组化染色有助于明确诊断。卵巢梁索型类癌预后非常好,未见转移报道。目前认为对该类患者进行完整的肿瘤切除并密切随访是比较合理的治疗方法。更多还原

【Abstract】 Objective:To investigate the clinicopathological features of trabecular carcinoid association with mature cystic teratoma.Methods:Two cases of trabecular carcinoid association with mature cystic teratoma were observed with gross,microscopic and immunohistochemical stains and discussed with literature reviewed.Results:The tumors were associated with teratomatouse elements and underwent the affected adnexa.On light microscopy,the tumor was composed of long,wavy ribbons,cords,or parallel trabeculae surrounded by fibromatouse connective tissue stroma that was usually dense.The ribbons,cords,or trabeculae were composed of columnar cells that form usually one but sometimes one to three layers.The nuclei were elongated or ovoid and contain finely dispersed chromatin.The cytoplasm was abundant and often contains granular eosinophilic granules.The immunohistochemistry was positive for chromogranin A,Synaptophysin,Ckpan and CD99.Conclusion:The diagnosis of trabecular carcinoid association with teratoma can be established on histopathologic,immunohistochemical and electron microscopic studies.The prognosis of patients with trabecular carcinoid of the ovary is favorable because these tumors are not associated with metastases.The optimal treatment is the excision of the affected adnexa,which results in a complete cure,but follow-up of the patient is advisable.更多还原