【摘要】 目的:探讨2型糖尿病患者颈总动脉内膜中膜厚度(IMT)和血清超敏C反应蛋白(HS-CRP)的相关性。方法:选取上海市中心城区460例30岁以上已诊断2型糖尿病的患者,采用免疫比浊法测定HS-CRP及用高敏感B型超声仪测定颈总动脉IMT。同时检测身高、体质量、腰围、臀围、血压及空腹血样检查。根据IMT检测结果分为IMT正常组(IMT<1.1mm)317例和IMT增厚组(IMT≥1.1mm)143例。结果:(1)采用Spearman相关分析显示颈总动脉IMT和年龄、病程、BMI、腰围、臀围、收缩压、舒张压、HS-CRP、空腹血糖、餐后2h血糖、糖化血红蛋白、血胆固醇、低密度载脂蛋白呈正相关(相关系数分别为r=0.438、0.182、0.105、0.146、0.116、0.328、0.187、0.217、0.131、0.119、0.093、0.094和0.113,P值均小于0.05。(2)逐步Logistic回归分析显示HS-CRP、年龄、收缩压、空腹血糖、血胆固醇是IMT增厚的独立危险因素(OR=1.048、1.106、1.023、1.354和1.357,P值均小于0.05)。结论:2型糖尿病患者颈总动脉内膜中膜厚度和血清HS-CRP相关,提示炎症可能是大血管病变的机制之一。更多还原

【Abstract】 Objective:This study aimed to investigate the relation between high sensitivity C-reactive protein(hs-CRP) and carotid intimal-medial thickness(IMT) in patients with type 2 diabetes. Methods: Serum hs-CRP was measured by immunonephelometry and the carotid intimal-medial thickness(IMT) was assessed using sensitive ultrasound B-mode in 460 patients with type 2 diabetes aged over 30 in downtown Shanghai. Body measurements including height,weight,waist circumference,hip circumference,resting blood pressure were performed.The patients were divided into normal IMT group(n=317)and thicker IMT group(n=143) depending the carotid IMT. Results: (1) Carotid intimal-medial thickness(IMT) was correlated with older age,duration,BMI,waist circumference, hip circumference,systolic blood pressure,diastolic blood pressure,hs-CRP, fasting blood glucose, postprandial blood glucose,glycosylated hemoglobin(HbA1C), serum cholesterol,Low Density Lipoprotein using Spearman correlation(r=0.438,0.182,0.105,0.146,0.116,0.328,0.187,0.217,0.131,0.119,0.093,0.094,0.113,respectively.P<0.05) (2) IMT was significantly associated with hs-CRP,age, systolic blood pressure,fasting blood glucose, serum cholesterol based on logistic regression analysis (OR=1.048,1.106,1.023,1.354,1.357,respectively.P<0.05). Conclusions:Hs-CRP is significantly correlated with carotid IMT,which suggests the inflammation might be one of the mechanisms of diabetic angiopathy.更多还原