【摘要】 目的:研究上海地区人类血小板抗原基因(HPA-1～16)多态性与脑梗死相关性。方法:采用PCR-SSP方法对103例上海地区脑梗死患者进行HPA1-16系统基因分型。结果:脑梗死组患者HPA-2b等位基因频率与正常对照组相互比较有差异(χ2=4.7201,P<0.05),脑梗死组患者的HPA-2b等位基因相关ab/bb基因型为30例(占29.13%),与正常对照组29例(占17.58%)相互比较有明显差异(χ2=4.2780,P<0.05);脑梗死组患者HPA-15a等位基因频率与正常对照组相互比较差异有统计学意义(χ2=20.2370,P<0.01),脑梗死组患者的HPA-15a等位基因相关aa/ab基因型为94例(占91.26%)与正常对照组134例(占81.21%)相互比较差异有统计学意义(χ2=4.2838,P<0.05)。结论:HPA-2b与HPA-15a等位基因可作为上海地区脑梗死患者的遗传易感性标志。更多还原

【Abstract】 Objective:To investigate the association between genetic polymorphism of human platelet antigens 1~16 (HPA-1~16) systems and cerebral infarction. Method:HPA 1~16 systems genotypes were applied to 103 Shanghai patients with cerebral infarction via sequence-specific (PCR-SSP). Result:There were difference (χ2=4.7201, P<0.05) between the frequency of HPA-2b allele of cerebral infraction group and the control group;and there were significant difference (χ2=4.2780,P<0.05) between the allele of HPA-2b of cerebral infraction with aa/bb genotypes (30 samples,29.13%) and the control group (29 samples, 17.58%). There were difference (χ2=20.2370, P<0.05) between the frequency of HPA-15a allele of cerebral infraction group and the control group. There were significant differences (χ2=4.2838, P<0.05) between the allele of HPA-15a of cerebral infraction group which had 94 samples of aa/bb genotype (91.26%) and the control group which had 134 samples (81.21%).Conclusion:The allele of HPA-2b and HPA-15a may be used as the standards of genetic susceptibility among the patients with cerebral infarction in Shanghai.更多还原