【摘要】 目的:探讨人类冠状动脉粥样硬化病变类型与内膜α-平滑肌肌动蛋白(α-SMA)含量的关系。方法:选用53例尸检病例的312块冠状动脉组织。经苏木精-伊红染色诊断冠状动脉粥样硬化病变及其类型,用免疫组化和Scion图像软件系统,测定和计算冠状动脉标本中α-SMA阳性面积%。结果:在冠状动脉粥样病变类型中,5%(16/312)为Ⅰ型,10%(31/312)为Ⅱ型,21%(66/312)为Ⅲ型,4%(14/312)为Ⅳ型,18%(55/312)为Ⅴ型和2%(6/312)为Ⅵ型。冠状动脉粥样硬化病变内膜α-SMA阳性面积%随着病变进展和管腔狭窄程度的加重而减少,分别呈负相关(r=-0.494,P<0.01,r=-0.362,P<0.01)。结论:人类冠状动脉粥样硬化病变内膜α-SMA阳性面积%随着冠状动脉粥样硬化病变程度的加重而减少。更多还原

【Abstract】 Objective:To study the quantitative analysis of α-SMA in differet type of human coronary atherosclerotic lesions.Method:A total of 312 blocks of coronary arteries were selected in 53 cases of autopsy.The pathological lesion types of coronary atherosclerosis were conformed by HE staining.Immunohistochemistry and Scion image software system were used to detect α-SMA-positive area.Result:Of 312 sections of coronary atherosclerosis lesion types and DIT,5%(16/312) was type I,10%(31/312) type Ⅱ,21%(66/312) type Ⅲ,4%(14/312) type Ⅳ,18%(55/312) typeⅤ and 2%(6/312) type Ⅵ.The percentage of α-SMA-positive area in the intima of coronary atherosclerosis was decreased as the progress of coronary atherosclerotic lesions and the aggravation of lumen narrowing,with the negative correlations between them respectively(r=-0.494,P<0.01,r=-0.362,P<0.01).Conclusion:The percentage of α-SMA-positive area in the intima of human coronary atherosclerosis is decreased depending on the progress of coronary atherosclerotic lesions and the aggravation of lumen narrowing.更多还原