【摘要】 目的:评估窄谱中波紫外线(NB-UVB)治疗白癜风的临床疗效及安全性;探讨NB-UVB对稳定期白癜风患者治疗前、后免疫功能的影响。方法:对138例不同临床类型稳定期白癜风患者的652片皮损予NB-UVB照射治疗,在治疗前、后采用散射比浊速率法及流式细胞仪检测其中42例患者外周血IgA、IgM、IgG、C3、C4及T细胞亚群水平。结果:经NB-UVB照射治疗,138例患者有效率为64.72%,平均照射10,12次时皮损处出现色素沉着斑点,面颈部及躯干部疗效显著,局限型及泛发型白癜风患者疗效尤佳。主要不良反应为瘙痒与干燥。42例白癜风患者外周血IgA、IgM、IgG、C3、C4及T淋巴细胞亚群水平在治疗前、后差异无统计学意义。结论:NB-UVB治疗白癜风疗效显著、见效快、不良反应少。NB-UVB对稳定期白癜风患者治疗前、后免疫功能无影响。更多还原

【Abstract】 Objectives:To evaluate the clinical efficacy and safety of narrow-band ultraviolet B(NB-UVB) therapy in the treatment of vitiligo and to investigate the influence of NB-UVB therapy on the immune fuction of the patients.Methods: One hundred and thirty-eight patients with stable vitiligo were treated with NB-UVB therapy.The serum levels of IgA,IgM, IgG,C3,C4 and the sub-populations of T lymphocytes were detected before and after treatment in 42 out of 138 patients. Results:The response rate of NB-UVB therapy was 64.72%.Repigmentation appeared after 10.12 times of treatment in average,which was more frequently be seen on the face,neck and trunk of the patients.More improvement was seen in the patients with localized or generalized vitiligo.Adverse reactions were mild erythema and pruritus.There were no statistical differences in the serum levels of immunoglobulins,complements and T lymphocyte sub-populations before and after treatment. Conclusions:NB-UVB therapy is a useful and well-tolerated treatment for stable vitiligo,without obvious influence on the immune function of the patients.更多还原