【摘要】 报告1例原发性皮肤弥漫性大B细胞淋巴瘤,腿型。患者女,77岁。因右胫前多发暗红色斑块和结节3个月入院。皮损组织病理检查示:肿瘤细胞在真皮内弥漫性浸润性生长,侵及皮下组织,肿瘤细胞体积增大,形态不规则,细胞核大深染,核分裂象多见。免疫组化染色示:瘤细胞CD20(+),CD79a(+),Bcl-2(+),MuM-1(+)。诊断:原发性皮肤弥漫性大B细胞淋巴瘤,腿型。通过CD20单克隆抗体加CHOP化疗方案治疗,病情明显好转。更多还原

【Abstract】 A case of leg type primary cutaneous diffuse large B-cell lymphoma is reported.A 77-year-old woman presented with multiple dark-red plaques and nodules on the anterior shin of her right leg for 3 months.Histopathology of the skin specimens showed a dense diffuse neoplastic cell infiltration in the dermis and subcutaneous fat tissue.The neoplastic cells were large and irregular in shape,their nuclei were large,dark-stained and irregularly shaped.Mitotic figures were also observed. Immunohistochemistry study showed positive staining for CD20,CD79a,Bcl-2 and MuM-1.She was diagnosed as primary cutaneous diffuse large B-cell lymphoma,leg type.Treated with anti-CD20 monoclonal antibody and CHOP chemotherapy, her condition was markedly improved.更多还原