【摘要】 目的:分析特应性皮炎(AD)患者血清抗马拉色菌及抗白念珠菌特异性IgE抗体水平与疾病严重程度的相关性,探讨其在AD发病中的作用。方法:收集符合Williams诊断标准的23例AD患者,对其严重程度以湿疹面积及严重度指数(EASI)评分法进行评分。以免疫荧光-酶技术测定23例AD患者、19名健康对照者的血清总IgE抗体水平、抗马拉色菌及抗白念珠菌特异性IgE抗体水平。分析该地区AD患者总IgE抗体水平、抗马拉色菌及抗白念珠菌特异性IgE抗体水平与疾病严重程度的相关性。结果:AD患者总IgE抗体水平、抗马拉色菌特异性IgE抗体水平高于健康对照者,并与EASI评分呈显著正相关(P<0.01)。结论:部分AD患者抗马拉色菌特异性IgE抗体水平升高,并与EASI评分呈正相关,提示马拉色菌在AD的发病中可能起一定作用。更多还原

【Abstract】 Objective:To analyse the correlation between the levels of specific IgE antibodies to the Malassezia yeasts and Candida albicans and the clinical severity of atopic dermatitis(AD).Methods:Twenty-three cases of AD who met the Williams criteria were collected in the study group.Nineteen healthy teenagers were collected in control group.Eczema area and severity index(EASI) score was estimated in the study group and the levels of total IgE and specific IgE antibodies to the Malassezia yeasts and Candida albicans were measured with fluorescence-enzyme immunoassay in both groups.Results:The levels of serum total IgE antibody and specific IgE antibodies to the Malassezia yeasts of AD were significantly higher than those of healthy controls.There was strong correlation between the levels of specific IgE antibodies to the Malassezia yeasts in serum and EASI score,as well as between the levels of total serum IgE antibody and EASI score.Conclusions:The levels of specific IgE antibodies to the Malassezia yeasts increased in some patients with AD and they correlated strongly with the EASI score.It showed that the Malassezia species may play a role in the pathogenesis of AD.更多还原