【摘要】 目的探讨小儿癌痛宁养治疗的安全性和有效性。方法选择41例2岁8个月～16岁、中晚期癌症患儿。按WHO癌症三阶梯镇痛原则,以宁养治疗方法给予口服镇痛药物:16例中度疼痛给予氨酚羟考酮0.1mg/kg,q4h;25例重度疼痛给予吗啡控释片0.4mg/kg,q12h。观察用药后镇痛效果、生活质量和不良反应。结果治疗后总体显效率为82.9%。治疗前、后总体生活质量评(45.87±24.11)分、(53.84±23.89)分(P<0.05)。主要不良反应有便秘20例(48.8%)、恶心和呕吐13例(31.7%)、嗜睡11例(26.8%),无呼吸抑制或成瘾等严重不良反应。结论宁养模式治疗小儿癌痛安全、有效,并能明显提高患儿的生活质量,它是门诊、住院治疗模式的有效补充。更多还原

【Abstract】 Objective To investigate the efficacy and safety of hospice care for the management of children’s cancer pain.Methods Fourty-one cases,aged from 2 years and 8 months to 16 years old,with moderate to severe cancer pain were administered compound capsule of oxycodone and acetaminophen 0.1 mg/kg q4h in 16 children with moderate cancer pain and morphine controlled-release table 0.4 mg/kg ,q12 h in 25 children with severe cancer pain.The efficacy of analgesia,quality of life and adverse events were observed.Results The total effective rate was 82.9% after management.The score of quality life increased frome initial 45.87±24.11 to 53.84±23.89 after management(P<0.05). The main adverse effects were constipation (20 cases,48.8%),nausea and vomiting (13 cases,31.7%) and somnolence (11 cases,26.8%). There were no respiratory depression and drug addiction.Conclusion Hospice care is a safe and effective method to relieve children’s cancer pain,which can prove the quality of life and provide a benefit way to control children’s cancer pain between the clinic and the hospitalization.更多还原