【摘要】 目的:探讨褪黑素改善伴有迟发性运动障碍(TD)的精神分裂症患者的认知功能及安全性。方法:76例伴有TD的慢性精神分裂症患者随机分为治疗组39例和对照组37例。治疗组给予褪黑素9mg/d,对照组只维持原药物治疗。疗程12周。采用韦氏成人智力量表(WAIS)、韦氏记忆量表(WMS)、重复性成套神经心理状态测验(RBANS)、词汇流畅性量表(VFT)及治疗中出现的症状量表(TESS),于治疗前和治疗12周分别评定疗效和不良反应。结果:治疗组WAIS在操作、言语及全量表总分上,RBANS在语义流畅性及VFT在所有指标上均显著高于对照组(P<0.05或P<0.01);两组WMS各指标差异均无统计学意义(P>0.05)。治疗组TESS评分较治疗前明显下降(P<0.05),两组间比较差异无统计学意义。结论:褪黑素能改善伴有TD的慢性精神分裂症患者的认知功能,且较安全。更多还原

【Abstract】 Objective:To explore the effect and security of melatonin on the treatment of cognitive impairment of the chronic schizophrenic inpatients with tardive dyskinesia.Method:76 inpatients who met with the criteria of schizophrenia and tardive dyskinesia(TD) were divided randomly into the treatment group and the control group.39 patients of treatment group were given melatonin 9 mg/d in the evening,only routine treatment was give to the control group.The efficacy and safety were assessed using Wechlors adult intelligence scale(WAIS)、Wechlors memory scale(WMS)、verbal fluency test(VFT)、repeatable battery for the assessment of neuropsychological status(RBANS) and treatment emergent symptoms scale(TESS) before treatment and in the end of week 12.Results:Compared with the control group,the treatment group did better on perfomance,verbal and full intelligence scale of WAIS,verbal fluency of RBANS and all measures of VFT(P < 0.05),but there was no significant difference on WMS between the two groups(P > 0.05) The score of TESS of the treatment group decreased after treatment but with no statistical significance.Conclusion:Melatonin is effective and safe in the treatment of the deficits of cognitive function in chronic schizophrenic inpatients with TD.更多还原