【摘要】 目的:探讨无痉挛电休克治疗(MECT)对精神分裂症患者多巴胺(DA)代谢产物高香草酸(HVA)的影响。方法:33例精神分裂症住院患者纳入研究,电休克治疗次数6～12次。应用阳性和阴性症状量表(PANSS)评定疗效,以高效液相紫外分光检测法测定患者治疗前后的血浆高香草酸(HVA)的含量。结果:患者治疗前、中、后HVA的含量差异有统计学意义(F=18.17,P=0.000),HVA含量与PANSS阴性症状和阳性症状评分均存在相关关系(r=0.560,0.373,P<0.05)。结论:电休克治疗前后HVA水平的变化与疗效相关,电休克治疗的机制之一是通过改变患者DA代谢发挥作用。更多还原

【Abstract】 Objective:To study the effect of modified electroconvulsive therapy(MECT)on the dopamine metabolite-the plasma homovanillic acid level in schizophrenics.Method:33 inpatients of schizophrenia were enrolled in the study,MECT was carried out for 6~12 times on each patient,the homovanillic acid(HVA)level determined by ultraviolet spectmphotometer(UV)and high performance liquid chromatography(HPLC)was measurated three times(before,3 weeks later and after the MECT).Positive and negative symptom scale(PANSS)was used to assess the effect of MECT.Results:The plasma homovanillic acid level in different treatent stage was statistically significantly different(F=14.115,P=0.000),the HVA level had correlation with the positive score and negative score of PANSS(r=0.560,0.373,P<0.05).Conclusion:The changes of HVA level before and after MECT has relationship with the curative effect,the plausiable mechanism of MECT is to take effect by influencing the metabolizability of dopamine neurotransmitter.更多还原