【摘要】 目的:探索精神分裂症、抑郁症患者一级亲属的注意功能特征。方法:对41例精神分裂症先证者的62例一级亲属、34例抑郁症先证者的55例一级亲属进行持续性操作测验(CPT)检测,并以54例精神正常者作为对照。结果:在反应时间分测验中,精神分裂症亲属组和抑郁症亲属组所有的CPT指标均高于对照组(P<0.05或P<0.01);大多数指标低于相应的患者组(P<0.05或P<0.01)。在X分测验中,针对靶刺激,上述两个亲属组的大多数CPT指标高于对照组(P<0.05或P<0.01);部分指标低于相应的患者组(P<0.05或P<0.01)。精神分裂症或抑郁症患者的部分CPT指标分别与其一级亲属呈显著性正相关(P<0.05或P<0.001)。在针对靶刺激的8项指标中,抑郁症亲属组有4项指标低于精神分裂症亲属组(P<0.05或P<0.01)。结论:精神分裂症和抑郁症患者的一级亲属都呈现出注意功能缺陷,但他们的CPT表现形式有所不同。从而提示,注意缺陷有可能是精神障碍的一项遗传易感因子,但他们并非精神分裂症所特有。更多还原

【Abstract】 Objective:To explore the feature of attention function in first-degree relatives of schizophrenic or depressive patients.Method:62 first-degree relatives of 41 schizophrenic probands and 55 first-degree relatives of 34 depressive probands were examined with continuous performance test(CPT),compared with 54 normal controls.Results:In reactive time,the scores of all items of CPT in the relative groups were significantly higher than those in normal controls(P<0.05 or P<0.01),and the scores of most of these items were lower than those in patient group(P<0.05 or P<0.01).In subtask X,as for the target stimulations,the scores of most items of CPT in the relative groups were obviously higher than those in normal control group(P<0.05 or P<0.01),while the scores of part of those items were lower than those in patient group(P<0.05 or P<0.01).Part of the items of CPT of patients in schizophrenic or depressive group were positively correlated with those in first degree relatives group respectively(P<0.05 or P<0.001).In the eight items of target stimulations,the scores of four items in depressive first relatives group were lower than those in schizophrenic first relatives group(P<0.05 or P<0.001).Conclusion:Attention deficits are presented in first-degree relatives of schizophrenic or depressive patients.However,there are some differences in the manifestation in CPT which suggest that impaired attention may be a genetic factor for psychotic disorder,but not only for schizophrenia.更多还原