【摘要】 目的:比较艾司西酞普兰与舍曲林治疗老年抑郁症的疗效和安全性。方法:80例老年抑郁症患者随机分为艾司西酞普兰组和舍曲林组,每组40例,分别给予艾司西酞普兰和舍曲林治疗8周。采用蒙哥马利-阿斯伯格抑郁评价量表(MADRS),于治疗前及治疗1、2、4、6、8周评价疗效,并观察不良反应。结果:治疗后两组MADRS评分均较治疗前明显下降;治疗各周的MADRS减分率以艾司西酞普兰组显著较高(P<0.05或P<0.01),起效更快,临床有效率和缓解率更高(P<0.05或P<0.01)。两组不良反应均较少,艾司西酞普兰组不良反应发生率较舍曲林组更低(P<0.05)。结论:艾司西酞普兰和舍曲林治疗老年抑郁症疗效确切,服药依从性好。艾司西酞普兰起效快,不良反应少,适合老年抑郁症的一线用药。更多还原

【Abstract】 Objective:To compare the effectiveness and safety of escitalopram and sertraline for elderly depression.Method:80 elderly depression were randomly divided into intervention group with escitalopram and controlled group with sertraline for eight weeks’ observation.Montgomery-asberg rating scale(MADRS) were used to evaluate therapeutic effects and adverse effects were observed at the pre-treatment and the end of 1,2,4,6,8 week after treatment.Results:MADRS were significantly reduced after treatment(P<0.05 or P<0.01).The deduction of total MADRS scores in escitalopram group was significantly higher than that in sertraline group at the end of week1,2,4 and 6(P<0.05 or P<0.01).Escitalopram worked earlier and was more effective than sertraline.Both groups have few adverse reactions;escitalopram group had fewer adverse reactions than sertraline group(P<0.05).Conclusion:Escitalopram and sertraline have similar therapeutic efficacy and good compliance in the treatment of patients with elderly depression,and escitalopram with rapid treatment effect and less adverse effects.Escitalopram could be the first-line of preferred antidepressants in the treatment of elderly depression.更多还原