【摘要】 目的:研究抑郁症患者血清胶质源性神经营养因子(GDNF)水平变化及其与生活事件之间的关系。方法:76例未经药物治疗的抑郁症患者(患者组),采用生活事件量表(LES)和汉密尔顿抑郁量表(HAMD)进行评定。用酶联吸附反应方法对患者进行血清GDNF检测,并与50名正常人(对照组)进行对照比较。结果:患者组血清GDNF水平平均为(343.3±201.3)pg/ml,显著低于对照组的GDNF水平平均(749.9±300.4)pg/ml(t=8.41,P<0.001)。以LES评分200分为界,将抑郁症患者分为高应激状态(n=23例)和低应激状态(n=53例),高应激状态患者的血清GDNF水平平均为(244.3±144.1)pg/ml,显著低于低应激状态患者的平均(386.2±208.5)pg/ml(t=2.97,P<0.001)。LES总分和血清GDNF水平之间呈显著负相关(r=-0.291,P<0.05)。结论:抑郁症患者可能存在GDNF水平下降,应激对血清GDNF水平可能有调节作用。更多还原

【Abstract】 Objective:To study the relationship between life events and serum glial cell line-derived neurotrophic factor(GDNF) levels in patients with depression.Method:76 patients with depression without drug treatment were assessed with the life event scale(LES) and the Hamilton depression rating scale(HAMD).Enzyme-linked immunosorbent assay(ELISA) was used to measure GDNF which was compared to that in 50 normal controls.Results:The serum levels(343.3±201.3) pg/ml of GDNF in patients with depression was significantly lower than the levels(749.9±300.4)pg/ml in control group(t=8.41,P<0.001).Patients with high stress had lower serum GDNF levels(244.3±144.1)pg/ml than patients with low stress the levels(386.2 ±208.5) pg/ml(t=2.97,P<0.001).LES score and serum levels of GDNF was negatively correlated(r=-0.291,P<0.05).Conclusion:GDNF levels of patients with depression may decrease,the stress may influence the serum levels of GDNF.更多还原