【摘要】 目的:探讨抑郁症患者的临床表现与儿童期受虐的关系。方法:120例抑郁症患者根据世界卫生组织(WHO)的儿童虐待定义分为受虐组44例,非受虐组76例;以100名健康志愿者为对照组。采用汉密尔顿抑郁量表(HAMD)评定抑郁症状严重度;韦氏记忆量表(WMS)评估认识功能;儿童期虐待史自评量表(PRCA)对患者儿童期受虐史进行测评。结果:与非受虐组相比,受虐组以女性较多,首次发病年龄较小,有偶者较少,单亲家庭、慢性病程及有自杀倾向较多;HAMD总分、焦虑/躯体化、认知障碍、绝望感因子评分均较非受虐组显著为高(P<0.05或P<0.01)。受虐组WMS中倒数、视觉再认、图片回忆、联想学习、触觉记忆、长时记忆、短时记忆及记忆商数得分显著低于非受虐组及对照组(P<0.05或P<0.01);PRCA中情感虐待、性虐待、忽视及虐待总分与HAMD总分及多个因子分、WMS总分及多个因子分呈负相关(P<0.05或P<0.01)。结论:有儿童期受虐史的抑郁症患者,其临床症状、记忆力损害较无儿童期受虐史的患者严重;临床症状的严重度与儿童期虐待有关。更多还原

【Abstract】 Objective:To explore the relationship between childhood abuse and clinical manifestation of patients with depression.Method:120 patients with depression and 100 healthy controls were assessed with Wechsler memory scale(WMS)and Hamilton depression scale(HAMD)to evaluate the cognitive function and depressive symptoms.All the patients were also investigated with personal report of childhood abuse(PRCA).According to the definition of childhood abuse made by world health organize(WHO),the patients with depression were divided into abused groups(n=44) and non-abused group(n=76).Results:The significant differences were found in gender,the first-episode age,course,marriage,family structure and suicidal trend between two groups.The total score and some factor scores were higher in the abused group than in the non-abused group(P<0.05 or P<0.01),while the scores of some items of WMS,including reciprocal value,visual recognition,picture recall,association learning,tactile memory,memory quotient,and so on,were significantly lower in the abused group than in the non-abused group and the control group(P<0.05 or P<0.01).The factor scores of emotional abuse,sexual abuse,neglect and total score of PRCA were negatively correlated to some factors of HAMD and WMS(P<0.05 or P<0.01).Conclusion:The depressive patients with childhood abuse have more severe clinical manifestation and memory impairment.更多还原