【摘要】 目的探讨原发性肝癌患者血清β2-微球蛋白(β2-microglobulin,β2-MG)含量变化及临床应用价值。方法用免疫放射分析法(RIA)检测64例原发性肝癌患者、55例肝硬化、以及48例正常健康人血清β2-MG含量;动态检测原发性肝癌手术前后β2-MG含量变化。结果原发性肝癌组血清中β2-MG含量明显高于健康对照组(P<0.05)和肝硬化组(P<0.05);原发性肝癌术前血清β2-MG含量增高者,术后含量明显降低,有转移复发时,β2-MG含量再度升高。结论检测血清β2-MG含量变化在原发性肝癌辅助诊断以及疗效、复发判断方面具有重要临床意义。更多还原

【Abstract】 Objective To study the clinical evaluation of serum β2-MG in hepatocarcinoma.Methods By using RIA,the levels of serum β2-MG of the health adults,patients with hepatocarcinoma,liver cirrhosis(LC),operative patients before and after operation.Results Serum β2-MG levels of hepatocarcinoma are higher than that of the health adults,patients with LC,In health adults and patients with LC there is no significantly difference of β2-MG.The high Serum β2-MG levels in preoperative patients were reduced dramatically after operation(P<0.01),however,the reduced Serum β2-MG levels raised again when matastasis or recurrence occurred.Serum β2-MG is a singly tumor marker.Conclusion The examination of serum β2-MG is helpful to the differential diagnose in hepatocarcinoma and LC;and has important significance in judgement of therapeutic effects and relapse for hepatocarcinoma更多还原