【摘要】 目的研究外周血CD19+及CD23+/CD19+细胞的表达在类风湿关节炎(RA)发病机制和病情进展中的意义。方法RA组和正常对照组各20例,应用流式细胞术检测外周血中CD19+及CD23+/CD19+细胞的表达率,比较两组的差异,并分析其与血沉(ESR)、C反应蛋白(CRP)的相关性。结果RA组外周血CD19+及CD23+/CD19+细胞表达率均高于对照组,(10.236±2.212)%vs(6.870±1.052)%,(5.134±1.069)%vs(2.100±0.652)%(P<0.05或<0.01)。CD23+/CD19+细胞的表达率与实验室指标ESR、CRP均呈正相关(P<0.01),CD19+细胞表达率与ESR、CRP无明显相关关系(P>0.05)。结论RA患者外周血存在CD19+及CD23+/CD19+细胞的表达增高,检测CD23+/CD19+细胞的表达情况可能对RA病情监控具有一定的应用价值。更多还原

【Abstract】 Objective To study the significance of CD19 + and CD23 +/CD19 + cell in peripheral blood of rheumatoid arthritis(RA) patients. Methods The percentage of CD19 + and CD23 +/CD19 + were detected with flow cytometry in 20 RA and 20 healthy controls.Association of ESR,CRP and its expression were analyzed. Results The prevalence of CD19 + and CD23 +/CD19 + cell in peripheral blood of RA patients were significantly higher than that in normal controls,(10.236 ± 2.212)% vs(6.870 ± 1.052)% and(5.134 ± 1.069)% vs(2.100 ± 0.652)%(P< 0.05 or < 0.01).Moreover,the expression of CD23 +/CD19 + cell but not CD19 + cells was positive correlated with the laboratory parameters of ESR and CRP. Conclusion The higher expressions of CD19 + and CD23 +/CD19 +cell were detected in the peripheral blood of RA patients.The CD23 +/CD19 + cell expression may have some value in monitoring the disease activity in RA patients.更多还原