【摘要】 目的探讨西酞普兰干预对伴发抑郁的冠心病患者疗效的影响。方法将63例伴有抑郁的冠心病患者随机分为对照组(常规治疗)和干预组(常规治疗+西酞普兰),进行为期6周的治疗,治疗前后分别观察患者症状缓解情况、心肌梗死溶栓试验(TIMI)危险积分的改变。用汉密尔顿抑郁量表评定患者抑郁情绪的变化情况。结果治疗后干预组和对照组心绞痛症状均较治疗前明显缓解,且干预组疗效优于对照组(P=0.035);TIMI危险积分比较,治疗后干预组下降幅度较对照组更明显(2.1±0.8 vs 2.6±1.2,P=0.000);干预组患者抑郁症状的改善优于对照组。从治疗前到治疗6周的HAMD评分,干预组和对照组分别为(29.2±6.5)分降至(11.7±6.1)分vs(28.5±7.1)分降至(16.8±6.9)分,两组差异有统计学意义(P<0.05)。结论西酞普兰干预对合并抑郁的冠心病患者有明显的辅助治疗作用。更多还原

【Abstract】 Objective To explore effect of citalopram on curative effect of coronary heart disease patients with depression.Methods Sixty-three coronary heart disease patients with depression were randomly divided into control group and study group,and the patients were respectively treated with general treatment and general treatment with citalopram.The effect was evaluated at pre-treatment and post-treatment six weeks,and TIMI risk scores and depressive degree were evaluated with TIMI and HAMD respectively.Results Symptom of angina after treatment mitigated compared with that before treatment in both control and study groups(P<0.05,respectively),and the degree of mitigating in study group was more obvious than that in control group(P=0.035);after treatment the degree of the TIMI risk scores decreasing in study group was more obvious than that in control group(2.1±0.8 vs 2.6±1.2,P=0.000).The improvement of depressive symptom in study group was better than that in control group.HAMD score in study group and control group decreased from pre-treatment to post-treatment six weeks,respectively(29.2±6.5) scores to(11.7±6.1) scrores vs(28.5±7.1) scores to(16.8±6.9) scores,the difference had statistic significance(P<0.05).Conclusion Citalopram has apparent adjunctive therapy effect on coronary heart disease patients with depression.更多还原