【摘要】 目的:研究转化生长因子β1(TGFβ-1)在声带息肉中的表达,探讨声带息肉的发病机制。方法:应用免疫组织化学SP法检测TGFβ-1在37例声带息肉(声带息肉组)及11例正常人声带(对照组)中的表达,并对其阳性表达结果进行比较。结果:TGFβ-1在声带息肉组中表达阳性率为56.76%,阳性细胞数为22.55±27.31;在对照组中表达阳性率为18.18%,阳性细胞数为2.53±3.75,两者相比均差异有统计学意义(均P<0.05)。TGF-β1在声带息肉组固有层浸润细胞的表达明显高于对照组声带组织。在声带息肉组中,男、女TGF-β1的表达差异无统计学意义(P>0.05)。结论:TGF-β1可能直接参与声带息肉的病理变化,促进细胞外基质积聚、局部纤维化,参与声带息肉的形成和发展。控制细胞因子TGFβ-1在声带息肉中的产生,可能为声带息肉的治疗提供一种新的方法。更多还原

【Abstract】 Objective:To analyze the expression of transforming growth factor-β1(TGF-β1)in human vocal fold polyps,and explore the pathogenesis of vocal fold polyp.Method:The expression of TGF-β1 were detected in 37 examples of vocal fold polys and 11 healthy vocal folds by immunohistochemical staining(SP method).Meanwhile,the positive results were compared.Result:The percent of positive expression of TGF-β1 was 56.76% and the number of positive cells was 22.55±27.31 in vocal fold polyps.both of which were significantly increased compared with the percent of positive expression of TGF-β1(18.18%) and the number of positive cells(2.53±3.75) in healthy vocal folds(P<0.05).The positive expression of TGF-β1 in stroma cells of vocal cord polyps was significantly higher than that in the healthy vocal cords.There was no significant difference of TGF-β1 between the vocal fold polyps of male and female(P>0.05).Conclusion:TGF-β1 may participate in some pathologic changes in vocal cord polyps,such as extracellular matrix accumulation,local fibrosis and formation and development of vocal cord polyps.Manipulating the TGF-β1 expression in vocal cord polyps may supply a new treatment method.更多还原