【摘要】 目的探讨冠状动脉轻中度狭窄病变斑块超声影像学特征与血清可溶性CD105水平的关系。方法102例冠心病患者分为轻中度狭窄和重度狭窄两组,对两组患者靶血管内超声特征与血清可溶性CD105水平进行相关研究。结果轻中度狭窄组血管内超声检出脂质斑块51例,占82.26%(51/62),其罪犯病变的血管外弹力膜面积(EEMA)、斑块面积(PA)、管腔面积狭窄率(LAS)及重构指数(RI)明显大于重度狭窄组,两组比较差异有统计学意义(均P<0.05)。两组间在纤维帽厚度、脂核或无回声带大小、脂核与斑块比之间存在统计学差异。血清可溶性CD105水平与RI呈正相关。结论易损斑块为偏心分布的低回声脂质斑块,具有较大的斑块面积和明显的正性重构;血清可溶性CD105参与了粥样硬化的形成,血清可溶性CD105水平可望作为预测冠状动脉轻中度狭窄病变斑块易损性的参考指标。更多还原

【Abstract】 Objective To assess the relationship between intravascular ultrasound(IVUS) features of plaques and blood serum soluble CD105 in angiographic mild coronary stenosis.Methods One hundred and two patients with coronary artery disease(CAD) were divided into mild stenosis group and serious stenosis group.The correlation of the IVUS features and blood serum soluble CD105 was analyzed.Results Fifty- one cases of soft lipid plaques were found in mild stenosis group by IVUS,82.26%(51/62),and their external elastic membrane area(EEMA),plaque area(PA),lumens area stenosis ratio(LAS)and remodeling index(RI) were larger than those of serious stenosis group,there was significant difference between two group(P<0.05).And there was significant difference in the thickness of fibrous cap,the size of lipid core and non - echo zone,the ratio of lipid core and plaque between the two groups.While there was positive correlation between soluble CD105 and RI.Conclusion Vulnerable plaques are eccentric soft lipid plaques with low level echo,and has larger plaque areas and obvious positive remodeling.Blood serum CD 105 participates in the formation of scleratheroma,its level can be reference index to predict plaque vulnerability of angiographic mild coronary stenosis.更多还原