【摘要】 目的分析川崎病(KD)患儿血小板数量与血小板生成素(TPO)、白介素3(IL-3)、白介素6(IL-6)的水平变化,探讨KD血小板升高的机制。方法川崎病患儿35例,正常对照儿童25例。全自动血细胞分析仪检测两组外周血血小板计数(PLT)、平均血小板体积(MPV)、血小板体积分布宽度(PDW),双抗夹心酶联免疫吸附法(ELISA)检测血清TPO、IL-3和IL-6水平。结果KD患儿急性期PLT数量有所增高,但与对照组比较,差异尚无统计学意义;恢复期PLT增高明显(P<0.001)。KD患儿急性期血清TPO、IL-3和IL-6水平明显增高,与对照组及恢复期比较,差异有统计学意义(P<0.001)。MPV在急性期也较恢复期及对照组明显增高(P<0.001)。相关分析显示,KD患儿血小板计数与TPO、IL-3、IL-6水平呈负相关,MPV与TPO和IL-6水平呈正相关。结论KD急性期血清细胞因子TPO、IL-3、IL-6等水平的升高可能是恢复期血小板数量增多的主要原因。更多还原

【Abstract】 Objective To study the number of platelet in children with Kawasaki disease and analyze its association with serum thrombopoietin(TPO),interleukin-3(IL-3) and interleukin-6(IL-6).Methods Thirty-five children with Kawasaki disease(KD) and 25 healthy children as control were recruited.Peripheral blood PLT,MPV,PDW were measured using automatic hematocyte analyzer and serum TPO,IL-3 and IL-6 levels were detected by ELISA methods.Results The number of platelet was slightly increased in acute phase((329.17±111.88)×109/L vs(275.12±71.09)×109 /L,(P>0.05)),and significantly increased in convalescent phase((528.54±185.22)×109 /L vs(329.17±111.88)×109/L,(P<0.001)).MPV in KD acute phase was also significantly higher than that in control group((8.68±1.33) fl vs(7.78±1.03) fl,(P<0.001)).The serum levels of TPO,IL-3 and IL-6 in acute phase were significantly increased than those in convalescent phase and those in control group.There were significant inverse correlations between the number of platelet and TPO,IL-3,IL-6 levels,and positive correlations between MPV and TPO,IL-6.Conclusions Elevation of serum TPO,IL-3 and IL-6 may be mainly responsible for thrombocytosis in Kawasaki disease.更多还原