【摘要】 目的:检测c-fos和基质金属蛋白酶13(matrix metalloproteinase 13,MMP13)在OSCC、癌旁组织和正常口腔上皮中的表达,探讨其与OSCC发生发展的关系。方法:免疫组化法检测和统计学分析。结果:c-fos表达在胞核内,MMP13表达在胞浆中,二者在OSCC中的阳性表达分别为67.3%及63.3%。c-fos和MMP13在有、无颈淋巴结转移组的阳性表达率分别为65.2%、69.2%(P(0.05)和78.3%、50%(P(0.05)。结论:c-fos表达与OS-CC病理分级相关,但与颈淋巴结转移无关。MMP13表达与OSCC病理分级和颈淋巴结转移均相关。更多还原

【Abstract】 Objective: To investigate the distribution and expression of c-fos and matrix metalloproteinase 13(MMP13) in OSCC,para-OSCC and normal oral epithelium and their role in the occurrence and development of OSCC.Methods: ElivisionTM plus was used.The immunohistochemical results were analyzed by statistical evaluation.Results: The expression of c-fos localized in the nucleus of the cell was 67.3% in OSCC.The expression of MMP13 localized in the cytoplasmic of the cell could be 63.3% in OSCCS.The positive rates of c-fos and MMP13 in lymph node metastasis and non-lymph node metastasis were 65.2% and 69.2%(P﹥0.05),as well as 78.3% and 50%(P﹤0.05),respectively.Conclusion: In OSCC,the expression of c-fos and MMP13 was related to differentiation.No significant correlation was observed between c-fos expression and lymph node metastasis.The positive expression of MMP13 increased significantly compared to lymph node metastasis.更多还原