【摘要】 目的:通过研究纳米二氧化钛(Nano-TiO2)种植体表面涂层材料的抗菌性能,为种植体表面材料的研发提供实验依据。方法:采用种植体周围炎可疑致病菌株牙龈卟啉单胞菌(Pg)、血链球菌(Ss)、金黄色葡萄球菌(Sa),以TC4(钛合金)为对照组比较两种材料的抗菌效果,并采用时效法测试时间长短对材料抗菌活性的影响。结果:采用贴膜法对Nano-TiO2涂层试件抗菌效果进行定量测试,对Pg、Ss、Sa的抗菌率分别为94.02%、99.34%、98.72%,实验组与对照组细菌量差异有统计学意义(P<0.05)。通过时效法测试时间长短对材料的影响,结果显示随着时间的推移,同一材料表面细菌量的差异无统计学意义(P>0.05)。结论:纳米二氧化钛涂层材料对3种可疑口腔致病菌均具有很好的抗菌效果,其抗菌性能优于TC4材料;其抗菌效果无时间依赖性,具有一定的抗菌稳定性和持久性,对于种植体周围炎的防治具有积极作用。更多还原

【Abstract】 Objective:In order to prevent periimplantitis,a nanomaterial of titanium material was coated on TC4.This study focused on the antibacterial effect of this thin film tested by P.gingivalis(Pg)、Streptococcus sanguis(Ss) and Staphylococcus aureus(Sa).Methods:The anti-bacterial circle diameters of Pg,Ss,Sa were tested for nanometer TiO2 coated discs.The number of the bacteria on the materials was investigated by means of clone form unit method.Anti-bacterial effects related to time-dependency were also tested.Results:The number of Pg,Ss and Sa on nanometer TiO2 were 1.4±0.5,3.0±1.5,4.4±1.1,while on TC4were 63.0±15.2,455.0±26.9,235.0±11.4 respectively.The amount of 3 kinds bacteria on the surface of TC4 was more than those on Nanometer TiO2(P<0.05).The results from illumination method,the antibacterial ratios of nanometer TiO2 against Pg,Ss and Sa were 94.02%,99.34% and 98.72% respectively.Conclusion:The nanometer TiO2 thin film on TC4 shows good antibacterial effects in vitro.更多还原