【摘要】 目的DNA氧化损伤标记物8-羟基脱氧鸟苷(8-OH-dG)分别与癌症和抑郁存在密切联系,本研究对该标记物与癌症相关性抑郁间的关系进行了探讨,分析其在癌症抑郁中诊断及评定程度中的临床意义.方法经病理确诊并使用17项汉密尔顿抑郁量表(HAMD)调查评定出的34例无抑郁的癌症患者(无抑郁组),抑郁患者53例,采用酶联免疫吸附法(ELISA)检测血清8-OH-dG水平.结果抑郁组和无抑郁组的平均8-OH-dG水平分别是(8.73±1.98)ng/mL和(5.44±0.69)ng/mL(t=-11.054,P<0.01).8-OH-dG水平与抑郁评分呈正相关(r=0.776),与是否是少数民族呈负相关(r=-0.214).逐步Logistic回归分析显示8-OH-dG(OR=7.196)是独立危险因素.结论检测外周血8-OH-dG水平可能有助于癌症相关性抑郁的早期诊断及病情判定.更多还原

【Abstract】 Objective To find out the pathophysiological mechanisms of cancer-related depression by examining group differences in serum levels of 8-hydroxy-2’-deoxyguanosine(8-OHdG),a biomarker of oxidative damage.Methods The samples consisted of 87 participants,and HAMD was used to examine depression.53 of these participants met diagnostic criteria for depression and 34 participants had no depression.8-OHdG was measured by enzyme-linked immunosorbent assay.Results Patients in the depressed group had significantly higher levels of oxidative DNA damage than participants in the control group[(8.73±1.98) ng/mL vs(5.44±0.69) ng/mL(t=-11.054,P<0.01)].Correlation analysis showed that scale of levels of 8-OHdG had correlation to scales of depression(r=0.776),and race(r=-0.214),respectively.Furthermore,Logistic regression showed that increased serum levels of 8-OH-dG was an independent risk factor of cancer-related depression(OR=7.196).Conclusion Detecting serum levels of 8-OHdG may contribute to the early diagnosis of cancer-related depression.更多还原