【摘要】 目的观察以莫西沙星为基础的7d三联疗法对根除Hpylori感染的临床效果.方法采用随机对照设计,214例Hpylori(+)患者分为两组,莫西沙星组:奥美拉唑20mgqd、莫西沙星0.4gqd、替硝唑0.5gbid;对照组:奥美拉唑20mgqd、克拉霉素0.5gbid、阿莫西林1.0gbid治疗7d,治疗结束4周后通过14C-UBT检查Hpylori是否根除.结果莫西沙星组Hpylori根除率为87.9%,对照组根除率为72.6%.两组之间的Hpylori根除率有显著性差异(χ2=6.779,P<0.05).结论以莫西沙星为基础的7d三联疗法是可供选择的Hpylori根除方案.更多还原

【Abstract】 AIM To observe the clinical effect of 7-day moxifloxacin-based therapies for Hpylori eradication.Methods In this random control study,214 H pylori-positive patients were divided into moxifloxacin (esomeprazole 20 mg qd,moxifloxacin 0.4 g qd,tinidazole 0.5 g bid) group and observe (esomeprazole 20 mg qd,Clarithromycin 0.5 g bid,amoxicillin 1.0 g bid) group.The patients in both groups were treated for 7 days.H pylori status was assessed 4 weeks after the end of treatment by 14 C urea breath test. Results The treatment was completed in all the 214 patients.The rates of H pylori eradication in moxifloxacin group and observe were 87.9% and 72.6% ,respectively,and there was statistical difference between them (χ2=6.779,P<0.05).Conclusion Seven-day moxifloxacin-based triple therapy is a feasible H pylori eradicati on method.更多还原