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结核分支杆菌对阿米卡星的耐药性研究

Analysis on drug resistance of mycobacterium tuberculosis to amikacin

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【作者】 谢永平陈广幸黎国梅李静宇秦河英

【Author】 XIE Yong-ping,CHEN Guang-xing,LI Guo-mei,LI Jing-yu,QIN He-ying.Antituberculosis Prophylactico-therapetic Institution of Zhaoqing City,Zhaoqing 526020,China

【机构】 广东省肇庆市结核病防治所

【摘要】 目的了解阿米卡星对耐药结核分支杆菌是否有效。方法5种不同浓度的抗结核药物培养基内加入结核分支杆菌浓度为0.1mg/mL的菌液0.1mL,4周后观察耐药情况。结果5种抗结核药物不同浓度,对结核分支杆菌有不同的敏感性和耐药性,其中以加入阿米卡星药物抗菌活性良好。结论阿米卡星为二线抗结核药物,对治疗耐药结核分支杆菌有效。

【Abstract】 Objective To investigate availability of amikacin to mycobacterium tuberculosis.Methods The mycobacterium tuberculosis solution(0.1 mg/mL,0.1 mL)was added into the mediums of five different concentrations of antituberculosis drugs.Four weeks later,the condition of drug resistance was viewed.Results Five different concentrations of antituberculosis drugs displayed different sensitivity and resistance,in which amikacin exerted strong antibacterial activity.Conclusion As a second choice antituberculosis drug,amikacin is effective for the treatment of drug-resistant mycobacterium tuberculosis infection.

  • 【文献出处】 检验医学与临床 ,Laboratory Medicine and Clinic , 编辑部邮箱 ,2009年04期
  • 【分类号】R446.5
  • 【被引频次】4
  • 【下载频次】94
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