【摘要】 目的探讨自体心包主动脉瓣替代实验猪麻醉方法的可行性及可靠性。方法氯胺酮、咪达唑仑基础麻醉下慢诱导,经猪口气管内插管、静脉复合全麻、呼吸机机械控制呼吸。芬太尼、丙泊酚和哌库溴铵维持麻醉。监测气管插管后及腹主动脉开放后动脉血气分析、电解质及血液指标变化。结果给猪行气管插管有相当难度,采用大号直喉镜片合并慢诱导气管插管完成全麻。麻醉全程中芬太尼用量3μg/(kg·h)镇痛;丙泊酚4mg/(kg·h)镇静;哌库溴铵0.27mg/(kg·h)维持肌肉松弛。结论应用氯胺酮、咪达唑仑、芬太尼、丙泊酚和哌库溴铵行静脉复合全麻,方法简单易行,可控性好,术后猪清醒迅速,是大型动物行复杂手术的良好麻醉方法。更多还原

【Abstract】 Objective To evaluate the feasibility and reliability of general anesthesia of swine in implantation of autologous pericardium into abdominal aorta valve. MethodsSixteen male or female domestic swines,weighting 22-43kg(range 29.75±6.26) kg,were used in this study. The swines were fasted for 12h before experiment,anesthetized with ketamin(6mg/kg) ,midazoplam(0.2mg/kg) ,and 0.3mg scopolamine and placed at a supine position on the operating table. The swines were intubated and mechanically ventilated with oxygen through an endotracheal tube. Anesthesia was maintained with propofol,fentanyl and arduan.(Sixteen pieces of autologous pericardial valve were implanted into the abdominal aorta valve by blocking the abdominal aorta.) The protocol was approved by the Animal Welfare Committee of Qingdao University and followed the Guidelines for the Care and Use of Laboratory Animals. Basic vital signs were observed and physical parameters,including electrolyte and arterial blood gas,were recorded during the procedures. ResultsEndotracheal intubation in swine was more difficult than in human beings. Anesthesia was maintained with propofol(4mg/(kg·h) and fentanyl 3μg/(kg·h) . In addition,arduan 0.27mg/(kg·h) was used as a skeletal muscle relaxant. All the swines became conscious immediately and lived well after operation. ConclusionKetamine,midazoplam and scopolamine can be used in anesthesia,and propofol,fentanyl and arduan can be used to maintain general anesthesia of swine in implantation of autologous pericardium into abdominal aorta valve.更多还原