【摘要】 目的探讨慢性充血性心力衰竭(chronic congestive heart failure,CHF)患者血清中肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)检测的价值。方法用放射免疫方法测定176例CHF患者和30例健康人血清中TNF-α、IL-6水平。比较分析CHF患者与正常人以及不同心功能程度的CHF患者之间TNF-α、IL-6水平的变化。结果CHF患者血清中TNF-α、IL-6水平明显高于正常对照组(P<0.05),且均随着心衰程度的加重而增高,呈高度正相关。不同程度心衰患者之间TNF-α、IL-6水平均有明显差异(P<0.01)。结论CHF患者存在免疫激活和心肌炎症反应,心衰程度越重,炎症反应也越明显。放射免疫方法测定TNF-α、IL-6对CHF病程及治疗疗效预后判断具有重要的价值。更多还原

【Abstract】 Objective To study the clinical significance of the detection of TNF-αand IL-6 in serum by RIA in Patients with Chronic Congestive Heart Failure.Methods The serum levels of TNF-αand IL-6 were determined by RIA in both 176 CHF cases with New York Heart Association Classification(NYHA) of grade Ⅱ to Ⅳ and 30 healthy physical examines as normal cases of control.Results There were insignificant differences in the serum levels of TNF-αand IL-6 between CHF patients with cardiac function of grade Ⅱ and control group(P>0.05).The serum levels of TNF-αand IL-6 were significantly higher in CHF patients above grade Ⅲ than that of control group(P<0.05),and there were significant differences between the CHF patients with cardiac function of grade Ⅱ and Ⅲ,grade Ⅱ and Ⅳ,grade Ⅲ and Ⅳ(P<0.01).The serum levels of TNF-αand IL-6 were increased with the severity of CHF.Serum IL-6 level was positively correlated with that of TNF-α(r=0.42,P<0.05).Conclusion Immunological activation and myocardial inflammation exist in CHF patients.The increasing levels of TNF-αand IL-6 can promote the onset and development of CHF.The detection of TNF-αand IL-6 in serum by RIA should be of great significance to the pathogenesis of CHF.更多还原