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丹参枳术饮的毒理学实验研究

Experimental Studies on the Toxic Effects of Danshenzhizhuyin

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【作者】 卢敏金纯郑晨果周璇

【Author】 LU Min1,JIN Chun1,ZHENG Chen-guo1,ZHOU Xuan2 1.Department of Chinese-wernsten’s rectal-anal,Wenzhou 3250272.Department of medicament,The second hospital Affiliated of WenZhou Medical College and University 325027

【机构】 温州医学院附属第二医院中西医结合肛肠科温州医学院附属第二医院药剂科

【摘要】 目的:观察丹参枳术饮的急慢性毒性反应。方法:ICR小鼠40只,随机分为2组,观察用丹参枳术饮灌胃后小鼠的急性毒性反应;SD大鼠40只,随机分为高、中、低剂量组和对照组各10只,观察用丹参枳术饮连续灌胃4周后的大鼠慢性毒性反应。结果:急慢性毒理实验均未发现明显的毒副作用。结论:丹参枳术饮是一种低毒的中药方剂,用于临床是安全的。

【Abstract】 Objective:To observe the acute and chronic toxicity of Danshenzhizhuyin(DSZSY).Methods:Forty healthy ICR mice were divided into two groups randomly for the acute toxic reaction after drug was given by affusing stomach.;Forty healthy SD rats were divided into four groups includes high-dose,middle-dose,slight-dose and control groups randomly for the chronic toxic reaction after drug was given by affusing stomach.Results:DSZSY doesn’t cause any toxic and chronic reaction on mice.Conclusion:DSZSY is a low-toxicity and relatively safe drug.

【关键词】 丹参枳术饮毒理学大鼠
【Key words】 DSZSYtoxicologymice
  • 【文献出处】 江西中医药 ,Jiangxi Journal of Traditional Chinese Medicine , 编辑部邮箱 ,2009年01期
  • 【分类号】R285.5
  • 【被引频次】2
  • 【下载频次】282
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