【摘要】 目的探讨血清肿瘤标志物癌胚抗原(CEA)、糖类抗原125(CA-125)、糖类抗原19-9(CA-19-9)、细胞角蛋白19片段(Cyfra21-1)、神经特异性烯醇化酶(NSE)联合检测对提高肺癌临床诊断的意义。方法采用酶联免疫法检测80例肺癌患者(肺癌组)、20例良性肺疾病(良性肺疾病组)及20例健康体检者(正常对照组)血清、CEA、CA-125、CA-19-9、Cyfra21-1、NSE的水平。结果肺癌组血清CEA、CA-125、CA-19-9、Cyfra21-1、NSE的水平均显著高于良性肺疾病组及正常对照组(均P<0.01),5项肿瘤标志物联合检测的敏感性和特异性明显优于单项检测(P<0.05)。结论CEA、CA-125、CA-19-9、Cyfra21-1、NSE对肺癌具有较高的辅助诊断价值,5项肿瘤标志物联合检测可显著提高肺癌诊断的敏感性和特异性。更多还原

【Abstract】 Objective To explore the clinical significance of combined detection of serum tumor markers carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA-125),carbohydrate antigen 19-9(CA-19-9),Cyfra 21-1 and neuron-specific enolase(NSE) of improve in diagnosis of lung carcinoma.Methods The levels of serum CEA,CA-125,CA-19-9,Cyfra 21-1 and NSE were detected with enzyme-linked immunosorbent assay in 80 cases of lung cancer(lung cancer group),20 cases of benign lung disease(benign lung disease group),as well as 20 cases of check human(normal control group).Results The levels of CEA,CA-125,CA-19-9,Cyfra 21-1 and NSE in lung cancer group were significantly higher than those in the benign lung disease group and in normal control group(all P<0.01).The sensitivity and specificity of five-tumor-marker-combined detection were higher than those in single-marker detection(P<0.05).Conclusion The serum CEA,CA-125,CA-19-9,Cyfra21-1 and NSE levels are of high auxiliary value in diagnosis of lung cancer.The combined detection of five tumor markers can significantly increase the sensitivity and specificity in lung cancer diagnosis.更多还原