目的探讨2型糖尿病(T2DM)患者发生动脉粥样硬化的危险因素。方法将118例2型糖尿病患者根据病变分为2组,A组60例,伴有大血管病变;B组58例,无大血管病变。2组进行生化放免指标测定,肝脏及颈动脉内膜中层厚度(IMT)进行超声检查,分析2组患者各危险因素之间的差异。结果与B组比较,A组IMT增加更明显(1.01±0.22 vs 0.84±0.16,P<0.05),非酒精性脂肪性肝病(NAFLD)的患病率更高(67.5%vs 47.5%,P<0.05);2组ALT、HbAlc、TC、LDL-C、HDL-C、BMI及HOMA-IR的均值间比较差异均有统计学意义(均P<0.05);TG均值2组比较差异无统计学意义(P>0.05)。多元回归分析提示2组患者颈动脉IMT与ALT、TC、LDL-C、HOMA-IR及BMI均相关;偏相关分析提示IMT与ACT独立相关。结论脂代谢异常、胰岛素抵抗、NAFCD与T2DM患者的动脉粥样硬化的发生和发展相关。
【英文摘要】
Objective To explore the risk factors of atherosclerosis in patients with type 2 diabetes mellitus(T2DM).Methods 118 cases of patients with T2DM were divided into two groups according to disease,group A of 60 cases,with macrovascular disease;group B of 58 cases,without macrovascular disease.The two groups had the determination of biochemical and radioimmunoassay indicators,liver and carotid artery intima-media thickness(IMT) were examed with ultrasound.The differences of the risk factors between two groups ...
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