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维生素K₂（20）的全合成

Total Synthesis of Vitamin K₂（20）

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【Author】 CHEN Hong1,WANG San-yong2,LI Chun-rong2,YANG Ding-qiao1,LONG Yu-hua1(1.School of Chemistry and Environment,South China Normal University,Guangzhou 510006,Guangdong,China;2.Guangdong Food Industry Institute,Guangzhou 510308,Guangdong,China)

【机构】华南师范大学化学与环境学院；广东省食品工业研究所；

【摘要】以甲萘醌为起始原料,经Diels-Alder反应,烷基化反应,逆Diels-Alder反应3步合成了具有药理活性的维生素K2(20)。与传统的直接烷基化法和格氏试剂法相比,该方法收率高、容易操作、反应条件温和。总收率59.1%。中间体及目标化合物Ⅺ经IR,1HNMR,13CNMR,MS确证。更多还原

【Abstract】 Pharmacological Vitamin K2 was synthesized from the starting material menadione in three steps,consisting of Diels-Alder reaction,alkylation,and retro-Diels-Alder reaction.Compared with conventional direct alkylation method and the method of using Grignard reagent,this method has the advantages of high yield,easy operation and mild reaction conditions.The overall yield was 59.1%.Intermediate and the target molecule Ⅺ were confirmed by IR,1HNMR,13CNMR and MS.更多还原