【摘要】 目的:探讨软组织多形性透明变性血管扩张性肿瘤(Pleomorphic hyalinizing angiectatic tumor of soft parts,PHAT)的临床病理特点。方法:对1例PHAT进行光镜观察和免疫组化检测,并结合文献进行讨论。结果:该病例为13岁女性,发现髂腰部皮下肿块半年。镜下肿瘤大部分区域表现为典型PHAT的形态学改变,而在肿瘤边缘和局灶肿瘤中可见"早期PHAT"改变。免疫标记:肿瘤细胞表达vimentin,SMA、Desmin,和S100呈弱阳性表达。随访25个月,未复发。结论:本例的观察结果支持早期PHAT是PHAT的先驱改变。PHAT应被视为交界性软组织肿瘤,组织学起源尚不清楚。熟悉这一新近认识的软组织肿瘤对于鉴别诊断和临床治疗具有重要意义。更多还原

【Abstract】 Objective:To study the clinic-pathological features of pleomorphic hyalinizing angiectatic tumor of soft parts(PHAT).Methods:A case of PHAT was examined by light microscopy and immunohistochemistry.Results:The subcutaneous solid tumor aris-ing in the right iliolumbus of a 13-year-old female had been present for six months prior to biopsy.On histological examination,the tumor contained both typical PHAT at most areas and early PHAT at the periphery and occasionally centrally located in the tumor.Im-munohistochemically,the tumor was positive for vimentin and also showed weak immunoreactivity to SMA,Desmin,and S100 protein.Follow-up data(25 months) showed no signs of local recurrence.Conlusion:The examination surports that early PHAT represents a precursor lesion for PHAT.PHAT should be considered mesenchymal tumors of intermediate malignancy and the cellular origin remains to be investigated.Recognizing this new entity is important for differential diagnosis and clinic treatment.更多还原