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DNA计算机原理、进展及难点(V):DNA分子的固定技术
DNA Computer Principle,Advances and Difficulties(V):Immobilization Technology of DNA Molecule
【摘要】 在DNA计算机的研制中,DNA分子的固定是首先需要处理的一个最为基本的技术问题.事实上,DNA分子的固定技术不仅是生物计算的一个基本技术,而且是整个基因工程、生物芯片、甚至某些疾病诊疗的基础.基于此,文中将对DNA分子的固定技术给予较为系统的研讨,包括基本原理、具体方法等.文中引入了"DNA分子固定系统"的结构体系,并对该结构体系中载体子系统、固定剂子系统、标记子系统这3个主要子系统进行了详细的论述.
【Abstract】 In the research of DNA computer,immobilization of DNA molecule is an essential technology at first.Actually,immobilization of DNA molecule is not only a basic tool of biological computation,but also the foundation of the whole Genetic Engineering and bio-chip,even some disease treatment.In this paper,immobilization technology of DNA molecule,including its basic principle and factual methods is discussed in detail.The architecture of bio-molecular immobilization system is presented.The authors mainly introduce its three subsystems—substrate system,fixer system and molecular marker system.
【Key words】 DNA computation; immobilization of DNA molecular; immobilization system; fixer; substrate; molecular marker; magnetic bead purification; AcryditeTM technology;
- 【文献出处】 计算机学报 ,Chinese Journal of Computers , 编辑部邮箱 ,2009年12期
- 【分类号】TP301
- 【被引频次】8
- 【下载频次】781