【摘要】 目的研究缺血后处理对缺血再灌注家兔心功能、体内丙二醛(MDA)含量及超氧化物歧化酶(SOD)活性的影响。方法18只家兔随机分为对照组、缺血预处理组和缺血后处理组(每组6只)。监测家兔缺血及再灌注时左室内压峰值(LVSP)、±dp/dtmax和再灌注后血清中MDA含量及SOD活力。结果与对照组比较,缺血预处理组及缺血后处理组LVSP及左室±dp/dtmax再灌注后的恢复率均高于对照组(P<0.01),血清MDA含量明显低于对照组(P<0.05),SOD活力明显高于对照组(P<0.05)。结论结果表明缺血后处理与通过抑制氧化应激能减轻家兔心肌缺血-再灌注损伤。更多还原

【Abstract】 Objective:To investigate the impact of ischemic preconditioning and ischemic postconditioning on cardiac function,malondialdehyde(MDA) and superoxide dismutase(SOD) during heart ischemia/reperfusion injury in rabbits.Methods:Eighteen rabbits were randomly divided into 3 groups(n= 6 each): control group,ischemic preconditioning group and ischemic postconditioning group.Left ventricular systolic pressure(LVSP),±dp/dtmax of the heart during reperfusion were determined.Ptasma MDA content and SOD activity were also measured.Results:Compared with those of control,LVSP and ±dp/dtmax of the heart were better recovered during reperfusion in both of the conditioned groups(P<0.01).The MDA concentrations in plasma in both of the conditioned groups were significantly lower than those in the control group(P<0.05) and the SOD activities in plasma were significantly higher than those in the control group(P<0.05).Conclusion:The results demonstrate that ischemic post-conditioning,like ischemic preconditioning,improve cardiofunction,depresses the production of oxygen free radicals and attenuate reperfusion injury in ischemic heart.更多还原