【摘要】 目的:探讨Tenascin-C(Tn-C)在乳腺导管原位癌中的表达及其意义。方法:应用免疫组化S-P方法检测52例乳腺导管原位癌Tn-C的表达,及其与ER、PR和HER-2等表达的相关性。结果:Tn-C表达阳性率为60%,其中Van-Nuys1组的阳性率为38%,Van-Nuys2组的阳性率为70%,Van-Nuys3组的阳性率为88%,组间阳性表达差异有统计学意义(P<0.01)。Tenascin-C的阳性表达和ER、PR阴性表达及HER-2阳性表达呈正相关(P<0.05)。结论:Tn-C可以作为判断乳腺导管原位癌恶性程度、预后的一个指标。更多还原

【Abstract】 Objective To investigate the expression of Tenascin-C (Tn-C) in ductal carcinoma in situ of the breast and its clinical significance. Method The expression of Tn-C, ER, PR and HER-2 were examined in 52 patients with ductal carcinoma in situ of the breast by S-P immunohistochemical technique.Results The positive rate of Tn-C was 60%, and its positive expression in Van-Nuys group 1, 2 and 3 was 38%,70% and 88%,respectively. There was significant difference among the three groups (P<0.01). Tenascin-C positive expression was strongly related to ER, PR negative expression and HER-2 positive expression (P<0.05). Conclusion Tenascin-C may be a tumor marker for clinics and a parameter for prognosis of ductal carcinoma in situ of the breast.更多还原