【摘要】 目的:文献报道脊柱融合对邻近节段退变的影响均集中在生物力学、影像学方面,缺少相关的实验研究,本文通过建立腰椎后外侧融合动物模型,观察其对邻近节段椎间盘退变的影响。建立腰椎后外侧融合动物模型,观察其对邻近节段椎间盘退变的影响。方法:后正中暴露兔腰4～6椎板及横突,用0.8mm钢丝行双侧腰4～6横突间8字内固定,然后用骨水泥包绕横突及钢丝。观察术后3个月、6个月时邻近节段椎间盘的病理改变。结果:组织学观察显示术后3个月时实验组L3-4椎间盘即有退变性改变,退变程度按Miyamoto分级为2级,至术后6个月时则退变更加明显,达3级。结论:腰椎后外侧融合会引起邻近节段椎间盘的退变加速。更多还原

【Abstract】 Objective:Reports about impact of lumbar posterolateral fusion on adjacent segment degeneration concentrated on biomechanics and imageology,lack experimental study. This study observes the impact of posterolateral arthrodesis on the adjacent intervertebral disc. To observe the impact of posterolateral arthrodesis on the adjacent intervertebral disc. Methods:Rabbit models of posterolateral arthrodesis were established and the transverse processes of the fourth,fifth and sixth lumbar vertebrae were exposed. Stainless-steel wire0.8 mm in diameter was used to interconnect the three transverse processes in a figure of 8. Methylmethacrylate was then applied to encircle the transverse processes and the wire. Changes in the adjacent disc were observed by light microscopy 3 and 6 months after the operation. Results:Disc degeneration was found at L3-4 at 3 months postoperatively,and further degeneration was noted at this level at 6 months. Conclusion:Posterolateral fusion may accelerate the degeneration of the adjacent intervertebral disc.更多还原