【摘要】 目的探讨西酞普兰与阿米替林治疗脑梗塞后抑郁症的疗效与安全性。方法将48例脑梗塞后抑郁症患者随机分成西酞普兰组与阿米替林组治疗8周,应用汉密尔顿抑郁量表(HAM D)和副反应量表(TESS)评定疗效及安全性。结果西酞普兰与阿米替林疗效相当,但西酞普兰起效快,不良反应轻,而阿米替林副反应大。结论西酞普兰治疗脑梗塞后抑郁症疗效好,起效快,不良反应轻,可作为脑梗塞后抑郁的一线用药。更多还原

【Abstract】 Objective To explore the efficacy and side effects between citalopram and amitriptyline in the treatment of post-celebral infarction depression.Methods 48 patients with post-celebral infarction depression were randomly divided into citalopram group and amitriptyline group,both treated for 8 weeks.The efficacy and side effects were measured with HAMD and TESS.Resules The drugs were similar in efficacy,but citalopram showed effects earlier and fewer side effects than amitriptyline,amitriptyline showed more side effects than Citalopram.Conclusion Citalopram was a safe and effictive drug with less side effect in the treatment of post-celebral infarction depression.更多还原