【摘要】 目的探讨CT灌注成像(CTPI)在老年性脑梗塞脑血流动力学研究中的价值。方法48例临床拟诊脑梗塞的患者,发病24h内行CT16层平扫及CTPI检查,测定兴趣区的脑血流量(CBF)、对比剂平均通过时间(MTT)和对比剂峰值时间(TTP),并与对侧相应脑组织灌注参数比较;所有病例3～10d后行MRI随访。结果本组中40.9%(18/44)的患者CT平扫显示缺血灶,93.2%(41/44)的患者CTPI显示异常灌注。CTPI发现异常灌注的敏感性为93.2%,特异性为100%;缺血区CBF减低,MTT、TTP延长,与对照区域比较差异显著,有统计学意义(P<0.01)。结论CTPI能够敏感地反映缺血脑组织的血流动力学状态,为老年缺血性脑梗塞的早期诊断、早期治疗提供重要信息。更多还原

【Abstract】 Objective To investigate the value of CT perfusion imaging(CTPI) in the hemodynamic study on the aged cerebral infarction.Methods 48 patients who were doubted with cerebral infarction underwent 16-slice CT plain scaning and CTPI within 24 hours of onset.The cerebral blood flow(CBF),mean transit time(MTT)and time to peak(TTP)in region of interest(FOV) were used as brain hemodynamic parameters to compare research regions with counterparts.All cases were followed-up with MRI 3～10 days after.Results Ischemia lesion was found on CT plain scaning In 40.9%(18/44)of patients,while 93.2%(41/44)of patients showed ischemia leision on CTPI.The sensibility of CTPI in identifying ischemia area was 93.2%,and the specificity was 100%.CBF in research area was reduced,MTT and TTP were increased,there was significant difference in hemodynamics between research region and counterparts(P<0.01).Conclusions CT perfusion imaging can sensitively reveal the cerebral haemodnamics of ischemia,which could provide the important information for early diagnosis and early treatment of aged brain infarction.更多还原